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KMID : 0369819910210010023
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 1 p.23 ~ p.32
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Studies on Solid Dispersion System of Ketoconazole
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이치호/Lee CH
김기헌/최우식/김정량/Kim KH/Choi WS/Kim JR
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Abstract
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Dissolution profiles of ketoconazole in solid dispersion system (SDS) were investigated in the second fluid (pH 6.8) for the dissolution test (KPV). PVP K-30 and methyl cellulose were used as carriers in SDS, and chloroform as a solvent. Computer optimization technique was applied to obtain an optimum formula of SDS, and the following results were obtained; 1) Dissolution rate of ketoconazole in SDS was larger than that of pure ketoconazole in the second fluid of pH 6.8. 2) PVP K-30 and methyl cellulosr were good carriers for SDS of ketoconazole. Moerover PVP K-30 was better than methyl cellulose. 3) The optimum formula of ketoconazole SDS obtained from computer optimization technique was chloroform 175 ml, PVP K-30 5g and methyl cellulose 0.2g per 1g of ketoconazole. 4) The experimental value of A60 (Amount released from ketoconazole tablet during 60 minutes) obtained from SDS by optimum formula agreed well with the value calculated by polynomial regression equation.
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KEYWORD
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Ketoconazole, solid dispersion system, computer optimization, contour graph
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